Panagiotis Giannios — researcher and genetic counsellor

Research

I investigate how progenitor and differentiated cell populations adjust gene-expression output and physiology in response to endocrine signals, stress and major developmental transitions. My work focuses on post-transcriptional regulation, mRNA metabolism and the dynamic organisation of RNA and proteins, particularly within RNP granules and biomolecular condensates formed through phase-separation processes.

I also study the limits of this adaptability: how physiological constraints, including increased genome content, biosynthetic demand and intracellular organisation, influence whether cells remain functional, undergo remodelling or become vulnerable to elimination. Development offers a controlled setting for identifying principles that may also explain maladaptive changes in cellular function during disease.

A complementary strand of my work lies at the interface of biology, physics, engineering and medicine. In biomedical optics, I have studied tissue optical properties, light–tissue interactions and their biological and potential clinical significance.

Genetic counselling

I provide counselling around hereditary predisposition to cancer, referral for specialised genetic testing and interpretation of results. This includes assessing personal and family history, supporting informed decisions, explaining uncertain or unexpected findings and considering possible implications for relatives.